Colorectal cancer comes in many forms, including adenocarcinoma, leiomyosarcoma, lymphoma, melanoma, and neuroendocrine tumors. Adenocarcinoma is the most common type of colorectal cancer. Signet ring cell adenocarcinoma is a rare type of adenocarcinoma, accounting for less than 1% of all colon cancers.
What Is an Adenocarcinoma?
“Adeno-” is a prefix that means “gland.” In general, glands secrete things and are classified as endocrine or exocrine. Endocrine glands secrete things into the bloodstream, like hormones. Exocrine glands secrete things that go outside of the body, like mucus and sweat.
A carcinoma is a malignant tumor that starts in epithelial tissue. Put the two words together and you get “adenocarcinoma,” which means a malignant tumor in epithelial tissue, specifically in a gland.
The term “signet ring cell” describes the appearance of cancer. To look at cancer cells under a microscope, you have to stain and dehydrate them. Because signet ring cell adenocarcinomas have so much fat in them, once they’re dehydrated, the nucleus gets pushed all the way over to one side. This makes the cell look kind of like a ring under the microscope.
Signet ring cell adenocarcinomas are considered more aggressive than regular adenocarcinomas and are harder to successfully treat.
Other Types of Colorectal Cancer
Adenocarcinoma Aggressive Neuroendocrine Tumor Leiomyosarcoma Lymphoma Malignant Melanoma Mucinous Adenocarcinoma
Symptoms of Colorectal Cancer
Though signet cell adenocarcinomas are aggressive and tend to develop at an earlier age than other types of colorectal cancers, the symptoms are the same:
Diarrhea or constipationA feeling that your bowel does not empty completelyBlood (either bright red or very dark) in your stoolStools that are narrower than usualFrequent gas pains or cramps, or feeling full or bloatedWeight loss with no known reasonFatigueNausea or vomiting
Because you may not have symptoms at first, it’s important to undergo screening tests. It is recommended that average-risk adults undergo colon cancer screening starting at age 45 (and earlier for those with risk factors). Screening includes colonoscopy and tests for blood in the stool. Treatments for colorectal cancer may include surgery, chemotherapy, radiation, or a combination.
