Common Side Effects
Those taking Orencia may experience mild side effects. Mild side effects typically disappear within days of the first dose and don’t cause any serious issues.
Some of the most common side effects include:
The common cold, a sinus infection, or other types of upper respiratory infections Headaches Nausea Sore throat
In children and adolescents taking Orencia, the common side effects are different and include:
Abdominal painDiarrheaCoughFever
Mild Allergic Reactions
Orencia can also cause a mild allergic reaction, possibly with a skin rash. Typically, these were found in less than 5% of participants in the clinical study and went away in days.
Symptoms of a mild allergic reaction to Orencia include:
Skin rash that may occur on any part of the bodySkin rash that occurs at the injection siteItchinessWarmth and redness of the skinRunny noseDizzinessHeartburnBack, leg, or arm pain
Serious Side Effects
Although rare, some people who take Orencia can experience serious side effects, which could potentially result in permanent damage, the need for emergency medical treatment and hospitalization, or death in some cases.
Infections
The use of Orencia can increase someone’s chances of getting infections, or it may worsen current infections. During clinical trials, infections were reported in 54% of participants being treated with the medication vs. 48% of people treated with placebo, with 3% being serious infections in the Orencia group and 1% in the placebo group. In very rare cases, these infections can be fatal. The most common organs affected are the lungs, kidneys, colon, urinary tract, and skin.
Symptoms of infection that could occur as a serious side effect of the medication include:
Fever or chillsCoughSkin that is red, warm, or painful to touchFatigueFlu-like symptoms
Severe Allergic Reactions
Orencia was found to cause severe allergic reactions in 1% of people in clinical studies. Symptoms of a severe allergic reaction include hives, swelling that occurs in the eyelids, lips, hands, feet, tongue, mouth, or throat, and difficulty breathing.
A severe allergic reaction can be life-threatening. If you notice any of the signs of a severe allergic reaction, call 911 for medical help immediately.
Cancer
Taking Orencia can increase your risk of developing cancer over time because of the effects it has on cell growth and multiplication. Compared with other drugs in the same class as Orencia, the most common type of cancer that may arise when taking Orencia is nonmelanoma skin cancer, but the overall increased risk is small.
Warnings
Orencia comes with several warnings, including hypersensitivity and anaphylaxis, serious infections like pneumonia and sepsis, and adverse events in COPD patients (rhonchi, shortness of breath, and worsening symptoms). People who are taking Orencia should not receive live vaccines while taking the medication or within three months of stopping the drug. There is also a warning regarding immunosuppression to Orencia use because it inhibits the body’s T-cell response and lower the body’s defense against infections.
You should seek emergency medical help if you experience the following symptoms:
Trouble breathingStabbing chest pain, wheezing, cough with yellow or green mucusPain or burning when you urinateSigns of skin infection such as itching, swelling, warmth, redness, or oozing
For people who are pregnant, Orencia should be used only when it is prescribed. Taking Orencia is not a reason to discontinue breastfeeding, however: Since abatacept is a large fusion protein, only small amounts would be expected to enter breastmilk. That said, if you’re nursing a newborn or preterm infant, talk to your rheumatologist about safety.
Interactions
The main drug interaction to be concerned about while using Orencia is with tumor necrosis factor (TNF) inhibitors or antagonists (also known as anti-TNFs). This type of medication is also used to treat arthritic autoimmune disorders, and includes Humira, Enbrel, and Remicade. People receiving both IV Orencia and TNF antagonist therapy experienced more infections (63%) and serious infections (4.4%) compared with those who were only on TNF antagonists. While transitioning from anti-TNFs to Orencia, people should therefore monitor for signs of infections.
A Word From Verywell
Dealing with an arthritic autoimmune disorder can be tough. The right medication can ease symptoms and help slow the progression of the disease, but it often comes with its own set of side effects. If you are thinking about taking Orencia or are already taking the medication, it’s important to talk with your healthcare provider about possible side effects and how best to minimize them. If you experience any of the side effects mentioned above and they become bothersome, there may be another medication that works better for you.
